| Date | Size | Title | Author |
| January 3, 2021 | 21 x 21 | BUSTING MOVES | Paolo Pasco |
| January 10, 2021 | 21 x 21 | OH, FOURPEAT'S SAKE! | Alex Bajcz |
| January 17, 2021 | 21 x 21 | DOUBLE-CROSSED | Tracy Gray and Tom Pepper |
| January 24, 2021 | 21 x 21 | SUGAR, SUGAR | Lucy Howard and Ross Trudeau |
| January 31, 2021 | 21 x 21 | PRODUCT MISPLACEMENT | Jim Hilger |
| February 7, 2021 | 21 x 21 | TODDLER TALK | Katie Hale and Christina Iverson |
| February 14, 2021 | 21 x 21 | SEALED WITH A KISS | Lisa Bunker |
| February 21, 2021 | 21 x 21 | KARAOKE BARS | Matthew Stock |
| February 28, 2021 | 21 x 21 | CROSSWORD BUFF | Brad Wiegmann |
| March 7, 2021 | 21 x 21 | TAKE TWO | Celeste Watts and Jeff Chen |
| March 14, 2021 | 21 x 21 | THEY ALL LAUGHED | Jacob Stulberg |
| March 21, 2021 | 21 x 21 | MORES | Julian Kwan |
| March 28, 2021 | 21 x 21 | OVER THE MOON | Olivia Mitra Framke |
| April 4, 2021 | 21 x 21 | GAME CHANGERS | Angela Olson Halsted and Doug Peterson |
| April 11, 2021 | 21 x 21 | MERGER MANIA | Dick Shlakman and Will Nediger |
| April 18, 2021 | 22 x 20 | A RARE FIND | Johan Vass |
| April 25, 2021 | 21 x 21 | STRETCHING EXERCISES | Jeremy Newton |
| May 2, 2021 | 21 x 21 | INITIAL IMPRESSIONS | Dan Schoenholz |
| May 9, 2021 | 21 x 21 | MOTHER'S DAY CONCERT | Brad Wiegmann |
| May 16, 2021 | 21 x 21 | A SHOT IN THE DARK | Joe DiPietro |
| May 23, 2021 | 21 x 21 | YOU DO THE MATH | Jennifer Nebergall |
| May 30, 2021 | 21 x 21 | GAME OVER | Adam Wagner |
| June 6, 2021 | 21 x 21 | OLIO | Robyn Weintraub |
| June 13, 2021 | 21 x 21 | MAPLE LEAF | Stephen McCarthy |
| June 20, 2021 | 21 x 21 | FAMILIAR SURROUNDINGS | Michael Lieberman |
| June 27, 2021 | 21 x 21 | GRAVITY'S RAINBOW | Ross Trudeau and Lindsey Hobbs |
| July 4, 2021 | 21 x 21 | I'VE GOT A FEELING ... | Howard Barkin |
| July 11, 2021 | 21 x 21 | NO RUSE | Ashish Vengsarkar |
| July 18, 2021 | 21 x 21 | DIG IN | Jesse Goldberg |
| July 25, 2021 | 21 x 21 | STAR SEARCH | Chandi Deitmer |
| August 1, 2021 | 21 x 21 | OFF BRAND | Matthew Stock |
| August 8, 2021 | 21 x 21 | JIGSAW PUZZLE | Christina Iverson and Jeff Chen |
| August 15, 2021 | 21 x 21 | THINK TWICE | Aimee Lucido and Ella Dershowitz |
| August 22, 2021 | 21 x 21 | RESETTLING LETTERINGS | Stephen McCarthy |
| August 29, 2021 | 21 x 21 | UH? OH ... | Dory Mintz |
| September 5, 2021 | 21 x 22 | GO UP IN SMOKE | Grant Thackray |
| September 12, 2021 | 21 x 22 | WHAT A CHARACTER! | Alex Rosen |
| September 19, 2021 | 21 x 21 | NEW LOOK | Peter Gordon |
| September 26, 2021 | 21 x 21 | STUDY BREAKS | Priyanka Sethy and Matthew Stock |
| October 3, 2021 | 21 x 22 | SNOOZEFEST | Trenton Charlson |
| October 10, 2021 | 21 x 21 | CLUE: THE MOVIE | Brandon Koppy |
| October 17, 2021 | 21 x 21 | COMMON CORE | Jeff Chen |
| October 24, 2021 | 21 x 21 | SPORTS NUTS | Katie Hale |
| October 31, 2021 | 21 x 21 | CHOICE WORDS | Alex Eaton-Salners |
| November 7, 2021 | 21 x 21 | THIS AND THAT | Sid Sivakumar |
| November 14, 2021 | 22 x 21 | HEADS OF STATE | Aimee Lucido and Ella Dershowitz |
| November 21, 2021 | 21 x 21 | SCREEN SHARING | Adam Wagner |
| November 28, 2021 | 21 x 21 | GARAGE SALE PITCHES | Jeff Kremer |
| December 5, 2021 | 21 x 21 | COME AGAIN? | Chase Dittrich and Jeff Chen |
| December 12, 2021 | 21 x 21 | JOB SHARING | Daniel Okulitch and Doug Peterson |
| December 19, 2021 | 21 x 21 | SEASON TO TASTE | Laura Taylor Kinnel |
| December 26, 2021 | 21 x 21 | PEST CONTROL | Christina Iverson |