1,577 search results for “mathematical modeling” in the Public website

Mathematical modelling of advanced herbal extraction
Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

Mathematical modelling of adverse outcome pathways
In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

PhD candidates on the Mathematical Modeling of Cardiovascular Development
Science, Mathematical Institute (MI)

PHD candidate, Mathematical modeling for prediction of liver toxicity
Science, Leiden Academic Centre for Drug Research (LACDR)

Prediction of spatialtemporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatialtemporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Mathematical modeling of cellular stress pathways for mechanistic understanding of chemicalinduced liver injury
Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyperactivated an adverse response takes place and cells die, which may lead to organismlevel toxicity such as druginduced…

Mathematical analysis of systems pharmacology models
Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Stadium wave in the nerves: a new mathematical model
Electrical signals travel like a wave through our neural pathways. The mathematical models for these movements could not yet properly describe all the biological properties of the nerves. PhD student Willem SchoutenStraatman changed this by improving the existing models. ‘I hope that one day we will…

Mathematical model predicts drug concentration in the brain
Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

Bioactivity based quality control for Chinese herbal medicine
Can we establish a new quality control system for herbal medicines that is based on bioactivity rather than a few abundant chemicals?

A mathematical model for a more diverse workforce
Many organisations have a biased workforce, even though diversity has so many advantages. Australian and Dutch researchers, including Leiden psychologist Romy van der Lee, have developed a solution based on a mathematical model. They published their findings in PLoS One on 28 July.

Mathematical Institute
The Mathematical Institute is responsible for the research and education in mathematics and statistics at Leiden University.

Quantitative biology of polar auxin transport and plant development
The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Cum laude PhD defence: natural seed bank drives diversity
Each year, poppies disperse seeds that grow into a new generation of flowers. Sometimes, some of the seeds postpone their germination for a few years, for example when they’re covered by a layer of sand. Only when the sand disappears, do they start to sprout. Margriet Oomen did mathematical research…

Preparing MFDEs for the Modelling World
Classical mathematical models treat space and time as a continuum, while it is sometimes more useful to regard it as granular. Hupkes is studying what this means for a number of important patterns that are often found in computer calculations and in nature.

Mathematical model helps to explain the formation of spine and ribs
Mathematical biologists from Leiden have developed a model that helps to explain how the spine and vertebrae, among other things, form during embryonic development. The same process, the other way around, plays a key role in cancer metastasis. Publication in iScience.

Mathematics
PhD candidates carry out a programme of independent research, leading to a PhD thesis in typically 4 years.

Mathematical Institute
Mathematics forms the basis of many innovations in technology, the service industry and science, such as data analysis and coding, artificial intelligence, weather or climate change modelling or understanding molecular processes. The researchers from the Mathematical Institute (MI) are constantly developing…

Multiscale mathematical biology of cellextracellular matrix interactions during morphogenesis
During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Mathematicsbased strategies for repairing tumour blood vessels
How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic wasteproducts and matrixdegrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?

Mathematics (MSc)
The master’s programme Mathematics at Leiden University focuses on analysis, probability and statistics, number theory and (arithmetic) geometry. It offers five specialisations ranging from Applied Mathematics to Mathematics and Business Studies.

Mathematics (BSc)
As a Mathematics student, you will learn to solve complex problems in creative ways using logical thinking and mathematical structures. A Mathematics degree will open many doors for you in society.

Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Theoryenriched practical knowledge in mathematics teacher education
This study looks at the question of how and at what level students in primary teacher education can integrate theory and practice, and how the organisation of their learning environment, focusing especially on mathematics and pedagogy, can contribute to that.

Mathematics and Education (MSc)
The master’s specialisation Mathematics and Education at Leiden University prepares students to teach the subject of mathematics to secondary school students. The programme comprises a oneyear mathematics component, followed by an education component in the second year.

Applied Mathematics (MSc)
The master's specialisation Applied Mathematics at Leiden University focuses on both computational and fundamental aspects of analysis and probability. It’s also an ideal basis for a PhD degree. Applied Mathematics is an excellent choice if you have the aspiration to pursue a PhD degree

PhD candidates in Mathematics
Science, Mathematical Institute (MI)

Ruben Huele
Science

Mathematics cluster STAR tenure track
Perform cuttingedge research in the area of the STAR mathematics cluster.

Mathematics and Business Studies (MSc)
The master’s specialisation Mathematics and Science Based Business at Leiden University bridges science and business development by focusing on areas such as technology management, innovation, entrepeneurship, operations, and decision making.

PhD candidates in Mathematical Statistics
Science, Mathematical Institute (MI)
 Teaching Mathematics (MSc)

reform: an empirical research about the implementation of national mathematics curriculum reform in China
This is a research project on the implementation of national mathematics curriculum reform in Chinese junior high school. The research is expected to provide insight into the ways and reasons of mathematics teachers in Chinese junior high school for implementing national curriculum reform.

Mathematics and Science Communication and Society (MSc)
The master’s specialisation Mathematics and Science Communication and Society at Leiden University bridges the gap between experts and the public by combining high quality research in mathematics with extensive training in science communication.

Anisotropy in cell mechanics
Mechanical interactions between cells and their environment play an important role in many biological processes.

Topics in mathematical and applied statistics
Promotor: A.W. van der Vaart

Abstract Behavioral Specification: unifying modeling and programming
We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Bayesian Statistics in Infinite Dimensions: Targeting Priors by Mathematical Analysis
Novel methods for understanding key aspects that are essential to the future of Bayesian inference for high or infinitedimensional models and data.

Anja RuetenBudde
Science

Computational modeling of angiogenesis: from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks

The Landscape Model
This computational approach to the complexity of text comprehension is useful for describing the cognitive processes involved.

Minimal structure modeling
Existing work in probabilistic language modeling can be mostly divided into two categories: (i) Purely sequential, stringlevel approaches ensure fluency at the local level without notion of grammaticality and seek improvements in the use of massive training corpora. (ii) Fully structural, treebased…

Biotic ligand models
Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005  2007)

Unraveling temporal processes using probabilistic graphical models
Reallife processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Adaptive Streaming Applications: Analysis and Implementation Models
Promotor: Prof.dr. E. Deprettere

Animal models for cutaneous vaccine delivery
Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Copromotor: Dr. B.E. SnaarJagalska

Bayesian Inference for Gaussian Models
This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Data Driven Modeling & Optimization of Industrial Processes
Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semibatch processes with many process steps, machine parameters and quality indicators.